Ribosomal Peptide-Bond Formation
نویسندگان
چکیده
منابع مشابه
Minireview Ribosomal Tolerance and Peptide Bond Formation
GTP hydrolysis, for the translocation of the mRNA chain and the tRNA molecules. Analysis of the three-dimensional structures of unbound ribosomal subunits from eubacteria (Figure 1A; Schluenzen et al., 2000; Wimberly et al., 2000; Harms et al., 2001) and archaea (Ban et al., 2000) as well as of the entire ribosome (Yusupov et al., 2001) clearly showed that the centers of the major ribosomal act...
متن کاملMechanism of ribosomal peptide bond formation.
The mechanism of peptide bond synthesis constitutes a fundamental and long-debated question in molecular biology. For many years, ribosomologists championed a protein-based mechanism, similar to the charge relay system that has been proposed for peptide hydrolysis by serine proteinases [references in (1)]. As it has become apparent that the peptidyl transferase center is composed mainly of RNA,...
متن کاملMechanism of Ribosomal Peptide Bond Formation
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Ribosomes, the universal cellular organelles catalyzing the translation of genetic code into proteins, are protein/RNA assemblies, of a molecular weight 2.5 mega Daltons or higher. They are built of two subunits that associate for performing protein biosynthesis. The large subunit creates the peptide bond and provides the path for emerging proteins. The small has key roles in initiating the pro...
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The peptidyl transferase center (PTC) is located in a protein free environment, thus confirming that the ribosome is a ribozyme. This arched void has dimensions suitable for accommodating the 3' ends of the A-and the P-site tRNAs, and is situated within a universal sizable symmetry-related region that connects all ribosomal functional centers involved in amino-acid polymerization. The linkage b...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2008
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2008.04.008